Day 2 :
Director for Informatics Program at Harvard Medical School, USA
Time : 10:00-10:40
Bhanu Bahl is Director for Informatics at Harvard Clinical and Translational Science Center. She is Director of the eagle-i semantic-search platform facilitating discovery of biomedical resources for translational science research across 38 academic/ not-for profit institutions. Bhanu is also director of software Quality Assurance Shared Services (QASS) at Harvard Catalyst supporting manual and automation QA needs for +37 informatics projects leveraging Best practices, technology and process optimization. She is also director of Shared Health Research Information Network(‘SHRINE’), a federated query application, which provides investigators the ability to perform population based research and feasibility studies across multi-hospital institutions. rnBhanu is a physician with a broad informatics background and has over 15 years of experience in overseeing technology projects in clinical and biological data repository; master data management; data standards; and content management.rn
Patient Cohort discovery, data sharing, and integration across multiple healthcare institutions is a challenge. Accrual of sufficient numbers of patients for rarer diseases clinical trials further compounds the challenge. The barriers arise due to variability in the source electronic health record (EHR) systems, in semantic interoperability and consistency of data elements, and in governance and regulatory policies across institutions. The Shared Health Research Information Network (‘SHRINE’), a Harvard Catalyst’s open source application, provides investigators with the ability to perform population based research and feasibility studies across multi-hospital institutions. The SHRINE web-based query tool returns aggregate numbers of patients across all sites with user-defined characteristics, currently demographics, diagnoses, medications, and selected lab values. The project leverages the use of the Informatics for Integrating Biology and the Bedside (‘i2b2’) Hive software, an open source scalable informatics framework, which enables a common platform and clinical data model at each institution to be networked across the web. Using federated search architecture, real-time queries can be performed across collaborating institutions, each with their own locally managed patient datasets. An example of SHRINE network is the Harvard Medical School affiliated participating institutions: Beth Israel Deaconess Medical Center, Brigham and Women’s Hospital, Children’s Hospital Boston, and Massachusetts General Hospital. Over 5.0 million patients, 890 million facts, and 4 categories of over 18,000 terms make up this instance of SHRINE.
Associate Professor in Mechanical Engineering.
Time : 10:40 – 11:20
Diego F Villegas is an Associate Professor in Mechanical Engineering. He obtained his PhD degree 4 years ago from Michigan Technological University. He has about 8 years of experience in the biomedical field, working on experimental and computational biomechanics. He has published about 6 articles in reputed biomedical journals. He is currently running undergraduate and graduate projects on prosthesis, orthosis, medical devices using computational and analytical tools.
Hands are strongly associated with sense of touch. Finger allows the hand to perform a lot of different activities. Therefore, losing part of a finger will change the biomechanics of the grip (Smith, 2007). Finger amputation is a surgical procedure to remove the phalanx involve in a trauma, which most of the time is a result of accidents. The motivation for this study was the difficulty of finding a group of finger amputees with different type of finger amputation. Then, this study seeks to establish the combination of finger amputation which is more critical in terms of losing handgrip force. Total finger amputation was not considered in this study. A cylindrical mechanical device was designed and built to emulate different eleven different combinations of finger amputations. It consists of eight gates which open by means of a motorized gear depending of what combination will be used to emulate amputated phalanx. A total of 10 adult subjects (five women, five men), right-handed, average height and weight, palm length less than 112 mm were used for this study. Subjects with muscular lessons, amputations, or any physical problem in hands or forearm did not participate on this study. Although several studies have found the force on each phalanx, or loss of handgrip in natural finger amputations, none of them had emulated finger amputations. Our results strongly agree with those found by Kong (Kong, 2005). Men handgrip force was found to be greater than women. However, handgrip force is reduced in 62% and 48.55% for men and women respectively in a combination including the distal and middle phalanx for index and middle fingers. Some of the results were expected and agree with previous studies. Notice that finger amputations in men are more critical than women, which suggest gender differences in hand biomechanics. This study will aid in the development of finger prosthesis, and hand rehabilitation.