Day :
Keynote Forum
Susan B Klein
Indiana University Bloomington, USA
Keynote: The particle therapy experience and recent developments
Time : 11:10-12:00
Biography:
Susan B Klein completed her PhD in Biophysics at University of California (Berkeley) in 1986. She completed her Post-doctoral training at University of Michigan in Biophysics and Radiation Oncology. After several years of bioengineering, she joined Indiana University Cyclotron Facility in 1990 where she examined proton radiation biology and began practicing medical physics. She is one of the seven intellectual property holders of the design, fabrication and operation of Midwest Proton Radiotherapy Institute. She is currently an Associate Director at Indiana University-Purdue University
Abstract:
Although particle therapy, particularly proton therapy is not a new technology having been initiated in 1952 at the University
of California at Berkeley cyclotron, it may be considered relatively new and certainly medical physicists are less familiar
with the clinical practice of particle therapy due to the scarcity of facilities worldwide. At last accounting, there were 67 facilities
in operation worldwide with another 49 under construction and a small fraction of the several thousands of linear accelerator
Xï€ray therapy facilities. As charged particles interact with matter in fundamentally different ways than neutral particles, the
planning and delivery of particle therapy requires a unique intuition based both on physics and on radiation biology. This
presentation will discuss the therapy, radiation machine design, radiation biology and clinical techniques relevant to particle
therapy.
Keynote Forum
Maria Elisabete C D Real Oliveira
Minho University, Portugal
Keynote: Monoolein-based nanocarriers for medical applications
Time : 12:00-12:50
Biography:
Maria Elisabete C D Real Oliveira is an Associated Professor with Habilitation at Physics Department of UMinho. She has completed her BSc in Physics, UCoimbra,
Portugal, 1975, and her PhD at the University of Salford, UK/University of Minho in 1986. She was Head of the Master’s Degree in Biophysics and Bionanosystems, UM (2009-2014), Head of the Research Group Atomic Molecular and Optics Physics, Centre of Physics, UM (2013-present) and President of the Group of Colloids and Polymer (Portuguese Chemical Society), since 2013. She is author of more than 54 full publications (ISI) in repute journals (h index-16) and author of 2 patents.
She was also Founder of the Spin-off Nanodelivery–I&D in Bionanotechnology, LDA
Abstract:
Over the past 30 years, liposomes have been used as key components in several therapeutic strategies, due to the structure,
biocompatibility, biodegradability and low toxicity of these self-assembled nanostructures. The physicochemical characteristics of liposomes have been found to be suitable for the encapsulation and therapeutic delivery of several water soluble molecules, including nucleic acids and proteins. Recently, our group has developed a liposomal formulation based
on the helper lipid monoolein (MO) and cationic lipids from the dioctadecyldimethylammonium family (DODAX) that has
shown great potential as a drug nanocarrier. In this work, we show that liposomal formulation, composed by DODAB:MO (1:2), can be a suitable nanocarrier for different molecules. DODAB: MO was developed as hybrid vector used for: (i) plasmid DNA (pDNA) and small interfering RNA (siRNA) delivery (ii) drug delivery and also as (iii) an adjuvant to present vaccine antigens to the immune system. The physicochemical properties of the nanocarriers were evaluated by dynamic light scattering (DLS), Differential Scanning Calorimetry (DSC) and Förster Resonance Energy Transfer (FRET). In vitro and in vivo assays were performed to assess the cytotoxicity, internalization, transfection efficiency or immunostimulation of the different
nanoparticles produced. Our results demonstrate that DODAB:MO (1:2) can efficiently deliver different molecules (pDNA, siRNA, drugs and Candida albicans cell wall surface proteins (CWSP), without inducing significant cytotoxic effects, which makes this a very versatile nanocarrier system with a great therapeutic potential.
- BioMedical Device Engineering | Bio Engineering | Radiation Oncology | Clinical Physics and Patient Safety | Biophysics | Bio Mechanics | Biomedical Physics | Dosimetry
Location: Barcelona, Spain
Chair
Susan B.Klein,
Indiana University Bloomington, USA
Co-Chair
Peter Ertl,
Vienna University of Technology, Austria
Session Introduction
Marta Drazkowska
Poznan University of Technology, Poland
Title: Evaluation of Different Knee Joint Kinematic Models
Biography:
Marta Drazkowska (maiden name Kordasz) has completed her Master Degree at the age of 25 years from Poznan University of Technology, Faculty of Computing, Chair of Control and Systems Engineering. In the same year she has began the PhD studies in the field of rehabilitation robotics. She has participated in the project aiming to construct the knee joint rehabilitation manipulator for patients with Ilizarov apparatus. Her main tasks included adaptive control of 1DOF flexible manipulator enabling execution of basic rehabilitation trainings, as well as the construction of
passive element altering the rotation axis in knee joint.
Abstract:
In this paper we focus on estimation of knee joint kinematics in sagittal plane. Assuming that the femur is a fixed segment during movement, the proper characteristic points are assigned on tibia. The proposed model, namely the Ellipse Normal Method (ENM), approximates the trajectories of each point by the ellipse curves. Therefore, the model could be easily incorporated in the design stage of rehabilitation manipulator.
The passive flexion movement for a seven year old subject, undergoing the distraction osteogenesis, is recorded via single plane fluoroscopy. Specific bone landmarks and shapes corresponding to tibial condyles and shaft are assigned on the images and are used as initial data. The real movement of tibia towards femur is compared with three different approximation models.
The following kinematic models are discussed: the arcs of two circles rolling on the flat plane (proposed by Iwaki et al.), ellipse rolling on another ellipse (proposed by Lee et al.), and ENM. The mechanical axes positions in the function of the flexion angle are evaluated for each presented model. The ENM proves to be the most reliable in terms of approximation of real knee movement.