Day 2 :
Keynote Forum
Peter Ertl
Vienna University of Technology, Austria
Keynote: Monitoring onset of bone healing kinetics and early transplant rejection using implantable titanium dioxide-coated bioimpedance sensors
Time : 10:00-10:50
Biography:
Peter Ertl holds an engineering degree in Biotechnology (BOKU, Austria), a PhD in Chemistry (Univ. Waterloo, Canada) and received his postdoctoral training as a biophysicist at University of California at Berkeley (US). Additionally, in 2003 Dr. Ertl co-founded a biotech start-up company where he served a number of years as Director of Product Development in Kitchener-Waterloo (CAD) developing benchtop-sized cell analyzers. In 2005 Dr. Ertl moved to Austria where he worked as Senior Scientist in the BioSensor Technology unit at the AIT Austrian Institute of Technology. In 2016 he was appointed Professor for Lab-on-a-Chip Systems for Bioscience Technologies at Vienna University of Technology, where his research focuses on the development of organs-on-a-chip and chips-in-organ systems for biomedical research
Abstract:
In Western societies the steady increase in human life expectancy is posing a significant socioeconomic challenge to maintain existing medical therapy standards and health care solutions for senior patients. It is also well known that elderly patients exhibit a significantly higher risk of complications following surgery. To prevent postoperative and long-term medical complications, an important strategy of medical traumatology involves repeated follow-up examinations using a variety of in vivo imaging technologies and in vitro assessment methods of biopsies. To improve early diagnosis of failed implant integration and tissue rejection, we have developed two implantable titanium dioxide-coated bioimpedance sensors to enable personalized therapeutic interventions during (1) impaired bone healing and (2) organ transplant rejection.
(1) In the case of endosseous implants, which are routinely applied in tissue reconstruction after long bone, spine and craniomaxillofacial injuries, the development of a prognostic non-invasive imaging technology capable of monitoring dynamic bone formation in situ is expected to deepen our understanding of osseous integration at the implant-tissue biointerface. Results of our study revealed distinct differences between granulation and soft tissue formation within two weeks after implantation, thus allowing the accurate assessment of bone healing prior the formation of a cortical bone layer in subcritical defects of rabbit calvaria.
(2) Every transplanted tissue and solid organ bears the risk of rejection, which can finally result in the loss of the transplant with falling back into disability or even death. Tissue biopsies are used today to detect and monitor tissue or solid organ rejection episodes. Detection of early stages of rejection and continuous monitoring can therefore prevent severe organ impairment or even loss of function. To overcome limitations of the state of the art rejection monitoring methods, we have developed titanium-dioxide coated implantable biosensors for transplant rejection monitoring.
Keynote Forum
Baki karaboce
National Metrology Institute of Turkey, Turkey
Keynote: Metrological approach in medical measurements
Biography:
Baki Karaböce has completed his PhD in Yeditepe Univertsity in Ä°stanbul in 2014. He is head of Medical Metrology Laboratory and Head of Medical Metrology Focus Group at National Metrology Institute of Turkey. He is member of EURAMET-The European Association of National Metrology Institutes, Task Group Health and Ultrasound subcommitte. He has published more than 30 papers in journals and has been serving as steering committe member of IEEE MeMeA-Medical Measurements and Applications Sympossium.
Abstract:
Test, measurement and calibration of medical equipments is becoming increasinglysignificant, when accuracy in diagnosis and effectiveness in treatment are required. Calibration andtesting of medical devices are one of the most important and critical issue in metrology field.Metrology link is not well established for measurements in medical field, hovewer metrological
traceability has been well established for measurements in technical and military field. For themedical device industry and applications in health sector, nothing counts more than the safety of a patient. Therefore all hospitals and medical equipment manufacturers have to perform periodic
testing and calibration of equipments, as a quality control regime that guarantees the reliability ofmedical devices. A feasibility study has been carried out and a report was published last year at TÜBÄ°TAK UME (The Scientific and Technological Research Council of Turkey, National Metrology Institute) in order to outline the current situation in the country and in the world. A roadmap were prepared for providing of reliability and metrological traceability in medical measurements. Medical metrology research laboratory has been established and a number of medical device design projects were initiated.
- BioMedical Device Engineering | Bio Engineering | Radiation Oncology | Clinical Physics and Patient Safety | Biophysics | Bio Mechanics | Biomedical Physics | Dosimetry
Location: Barcelona, Spain
Chair
Susan B.Klein,
Indiana University Bloomington, USA
Co-Chair
Peter Ertl,
Vienna University of Technology, Austria
Session Introduction
Marta Drazkowska
Poznan University of Technology, Poland
Title: Evaluation of Different Knee Joint Kinematic Models
Biography:
Marta Drazkowska (maiden name Kordasz) has completed her Master Degree at the age of 25 years from Poznan University of Technology, Faculty of Computing, Chair of Control and Systems Engineering. In the same year she has began the PhD studies in the field of rehabilitation robotics. She has participated in the project aiming to construct the knee joint rehabilitation manipulator for patients with Ilizarov apparatus. Her main tasks included adaptive control of 1DOF flexible manipulator enabling execution of basic rehabilitation trainings, as well as the construction of
passive element altering the rotation axis in knee joint.
Abstract:
In this paper we focus on estimation of knee joint kinematics in sagittal plane. Assuming that the femur is a fixed segment during movement, the proper characteristic points are assigned on tibia. The proposed model, namely the Ellipse Normal Method (ENM), approximates the trajectories of each point by the ellipse curves. Therefore, the model could be easily incorporated in the design stage of rehabilitation manipulator.
The passive flexion movement for a seven year old subject, undergoing the distraction osteogenesis, is recorded via single plane fluoroscopy. Specific bone landmarks and shapes corresponding to tibial condyles and shaft are assigned on the images and are used as initial data. The real movement of tibia towards femur is compared with three different approximation models.
The following kinematic models are discussed: the arcs of two circles rolling on the flat plane (proposed by Iwaki et al.), ellipse rolling on another ellipse (proposed by Lee et al.), and ENM. The mechanical axes positions in the function of the flexion angle are evaluated for each presented model. The ENM proves to be the most reliable in terms of approximation of real knee movement.